Dr. Ines Debove and Professor Kay Redfield Jamison discuss a challenge that appears across both neurological and psychiatric conditions: the loss of insight. In bipolar disorder, for example, people experiencing a manic phase often feel energized, powerful, or unusually clear-minded, without realizing that these sensations are actually symptoms of illness. Dr. Debove Debove draws a parallel to impulse control disorders in Parkinson’s disease, when certain medications trigger impulse control disorders such as compulsive gambling, shopping, or hypersexuality. Patients may not see these behaviors as part of their treatment side effects, making early recognition especially important.In both cases, the lack of awareness makes intervention difficult. Professor Jamison emphasizes that this is a core problem in treatment, underscoring the need for early detection, careful monitoring, and involvement of clinicians and trusted others to help people regain control and protect their well-being.