Mania, Depression, and the Role of Dopamine in Parkinson’s Disease In this episode, we explore the complex neuropsychiatric fluctuations seen in Parkinson’s disease and consider possible parallels with late-onset depression, postpartum depression, and late-onset mania. Renowned clinical psychologist and author Prof. Kay Redfield Jamison who has written extensively, and from personal experience, about manic depression joins neurologist Dr. Ines Debove, a specialist in movement and neurodegenerative disorders. Together, they discuss: What vulnerability factors contribute to neuropsychiatric changes in Parkinson’s, and what do these reveal about the course of the disease? A thought-provoking dialogue at the intersection of neurology and psychiatry, emotion and neuroscience.